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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HSF1 All Species: 0.91
Human Site: S221 Identified Species: 2
UniProt: Q00613 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.3
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q00613 NP_005517.1 529 57260 S221 N D S G S A H S M P K Y S R Q
Chimpanzee Pan troglodytes XP_001161258 492 53052 I185 H G Q Q H R V I G K L I Q C L
Rhesus Macaque Macaca mulatta XP_001108944 517 58258 K210 N T N G A Q K K N L F Q H I V
Dog Lupus familis XP_849103 517 56003 I209 I L G V K R K I P L M L N D G
Cat Felis silvestris
Mouse Mus musculus P38532 525 57205 N217 P L M L S D S N S A H S V P K
Rat Rattus norvegicus NP_077369 525 57091 S217 P L M L S D S S S A H S V P K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512133 411 44232 F104 S G I K S E D F K V R Q D N V
Chicken Gallus gallus P38529 491 53580 K183 E V A S L R Q K H A Q Q Q K V
Frog Xenopus laevis P41154 451 49454 M144 L I S D V Q S M K G K Q E S I
Zebra Danio Brachydanio rerio NP_571675 538 59923 K227 S S A H S M P K F S R Q Y S L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P22813 691 76915 V324 V D Y S N Q S V E D L L L Q G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 38 37.8 89.4 N.A. 89.4 89.4 N.A. 58.4 74.4 55 58.5 N.A. 29.5 N.A. N.A. N.A.
Protein Similarity: 100 51.9 55.5 92.4 N.A. 93.1 93.3 N.A. 65.9 83.9 64.8 72.1 N.A. 45.1 N.A. N.A. N.A.
P-Site Identity: 100 0 13.3 0 N.A. 6.6 13.3 N.A. 6.6 0 13.3 6.6 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 6.6 26.6 6.6 N.A. 20 20 N.A. 20 20 13.3 26.6 N.A. 20 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 19 0 10 10 0 0 0 28 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % C
% Asp: 0 19 0 10 0 19 10 0 0 10 0 0 10 10 0 % D
% Glu: 10 0 0 0 0 10 0 0 10 0 0 0 10 0 0 % E
% Phe: 0 0 0 0 0 0 0 10 10 0 10 0 0 0 0 % F
% Gly: 0 19 10 19 0 0 0 0 10 10 0 0 0 0 19 % G
% His: 10 0 0 10 10 0 10 0 10 0 19 0 10 0 0 % H
% Ile: 10 10 10 0 0 0 0 19 0 0 0 10 0 10 10 % I
% Lys: 0 0 0 10 10 0 19 28 19 10 19 0 0 10 19 % K
% Leu: 10 28 0 19 10 0 0 0 0 19 19 19 10 0 19 % L
% Met: 0 0 19 0 0 10 0 10 10 0 10 0 0 0 0 % M
% Asn: 19 0 10 0 10 0 0 10 10 0 0 0 10 10 0 % N
% Pro: 19 0 0 0 0 0 10 0 10 10 0 0 0 19 0 % P
% Gln: 0 0 10 10 0 28 10 0 0 0 10 46 19 10 10 % Q
% Arg: 0 0 0 0 0 28 0 0 0 0 19 0 0 10 0 % R
% Ser: 19 10 19 19 46 0 37 19 19 10 0 19 10 19 0 % S
% Thr: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 10 10 0 10 10 0 10 10 0 10 0 0 19 0 28 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 10 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _